New structure of key protein holds clue for better drug design

New structure of key protein holds clue for better drug design

Scientists at The Scripps Research Institute (TSRI) have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. The protein, called the A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals.The new, more detailed image of A2aAR’s signalling mechanism reveals key parts of its inner workings, including an amino acid that acts like a “toggle switch” to control signals across the cell membrane. Read More


According to the United Nations, water shortages will affect two-thirds of the world’s population by 2025 if current consumption patterns continue.1 CERAFILTEC, a manufacturer of innovative water filtration solutions, is helping to address this looming potential crisis with a unique new water filtration module molded from SABIC’s NORYL™ FE 1630PW glass-reinforced polyphenylene ether (PPE) resin.CERAFILTEC’s new filtration module features an all-advanced resin design. Read More


In a lot of ways, understanding quantum mechanical equations in an effort to predict what will happen between reactants such as atoms and molecules resulting in complex phenomena in chemistry can be exhausting, and mind-boggling to many. Yet, without the theoretical insights, experimental chemists would largely be unable to understand what they are observing. Researchers at The University of New Mexico, led by distinguished professor of chemistry Hua Guo, have been working with experimentalists to help them gain an understanding by providing theoretical interpretations of experimental observations. Read More
Royal DSM and Amyris Inc said that they have closed the transaction for the sale of Amyris Brasil Ltda to DSM and the establishment of a long-term manufacturing partnership for Amyris’s high-volume products. Read More